Neuroscience Day 2018 - Poster Presentations

4.  Using forebrains organoids to model FOXG1 sundrome - an autistic spectrum disorder. Jonothon Marshall (1), Sally Lowell (2), John Mason (1). (1) Centre for Discovery Brain Sciences, (2) Scottish Centre for Regenerative Medicine

5.  Can we target local translation to improve axonal regeneration in MS? Susan van Erp(1), AA van Berkel(1,2), EM Feenstra(1), JW Fawcett(3), C ffrench-Constant(1) 1: MRC Centre for Regenerative Medicine, The University of Edinburgh, UK, 2: Centre for Neurogenomics and Cognitive Research, VU University, Amsterdam, the Netherlands, 3: Cambridge Centre for Brain Repair, Cambridge, United Kingdom

6.  Development of a High-Throughput Drug Screening Platform for Oligodendrocyte Myelination 1 (Jee Soo) Monica Kim, 1 Dr. Marie Bechler, 2 Anthony Buchoux, 3 Dr. Maaria Ginai, 2 Dr. Adam Stokes, 3 Dr. Anthony Callana, 4 Professor Mark Bradley, 5 Professor Neil Carragher, 1 Professor Charles ffrench-Constant 1 MRC Centre for Regenerative Medicine; 2 Scottish Microelectronics Centre; 3 School of Engineering, University of Edinburgh; 4 School of Chemistry, University of Edinburgh; 5 Cancer Research UK Edinburgh Centre

7.  Distinct damaging and protective microglia subpopulations regulate pathology in perinatal white matter injury Graeme Ireland1*, Rebecca Holloway1, Julie-Clare Becher2, David H. Rowitch3, Colin Smith4, Jane E. Norman1, Pierre Gressens5, Veronique E. Miron1 1. MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh; 2. Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh; 3. Department of Neurological Surgery, University of California San Francisco; 4. Centre for Clinical Brain Sciences, The University of Edinburgh; 5. Department of Perinatal Imaging and Health, Rayne’s Institute, Kings College London

8.  CNS remyelination is driven by microglia necroptosis and repopulation Amy F. Lloyd1, Claire L. Davies1, Graeme Ireland1, Alessandra Dillenburg1, Rebecca K. Holloway1, Eva Borger2, Jill C. Richardson3,  Tanja Kuhlmann4, Anna Williams2, Jeffrey Pollard1, Josef Priller5,6, Veronique E. Miron1 1.MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh;  2. MRC Centre for Regenerative Medicine, The University of Edinburgh;  3. Neurosciences Therapeutic Area Unit, GlaxoSmithKline R&D, Stevenage, Herts; 4. Institute of Neuropathology, University Hospital Muenster, Germany;  5. Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité Universitätsmedizin Berlin, Germany;  6. UK Dementia Research Institute, The University of Edinburgh

9.  Myelin remodelling in the zebrafish central nervous system J Williamson, D Lyons Centre for Discovery Brain Sciences

10.  An automated chemical screen in zebrafish identifies novel regulators of myelination Katy Cole, Jason Early, Rafael Almeida, Rebecca Holloway, Veronique Miron, David Lyons Centre for Discovery Brain Sciences, University of Edinburgh

14.  An in-vitro model for focal demyelination in spinal cord slices of mice Sowmya Sekizar, Alexander Janssen, Anna Williams Scottish Center for regenerative medicine, University of Edinburgh

15. A novel model of Neuronal Ceroid Lipofuscinoses (NCL): development and characterization S.L.Eaton1, C.Proudfoot1, S.G.Lillico1, G. Thompson2, T. Schwartz3, M. Llavero1,  J.Nixon1, P.Tennant1, K.Hamer3, N. Rzechorzek3, E. Clutton4, C.B.Whitelaw1 &  T.M.Wishart1&5.  1  Roslin Institute, University of Edinburgh; 2 Centre for Clinical Brain Sciences, Chancellor's Building, University of Edinburgh; 3 Royal (Dick) School of Veterinary Studies, Easter Bush Research Campus, University of Edinburgh; 4 Wellcome Trust Critical Care Laboratory for Large Animals, Roslin Institute, Easter Bush Research Campus, Univeristy of Edinburgh;   5 Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh.

16.  A human pluripotent stem cell-derived in vitro model of myelination Owen Gwydion James, Bhuvaneish T. Selvaraj, Dario Magnani, Navneet Vasistha, Samantha Barton, Karen Burr, David Story, Charles ffrench-Constant, Siddharthan Chandran Centre for Clinical Brain Sciences;  Euan MacDonald Centre for Motor Neurone Disease; UK Dementia Research Institute; MRC Centre for Regenerative Medicine. All The University of Edinburgh.

Cellular & Molecular

11.  *Planar polarity signalling patterns the CNS myelin sheath Andrew A. Jarjour(1), Amanda Boyd(1), Kathryn Topham(1), Deborah J. Henderson(2), Charles ffrench-Constant(1) 1 MRC Centre for Regenerative Medicine and MS Society/University of Edinburgh Centre for Translational Research, Scottish Centre for Regenerative Medicine, The University of Edinburgh, 2 Institute of Genetic Medicine, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne

17.  Studying regulation of myelination by axonal vesicle release Rafael Almeida, Sarah Lewis, David Lyons Centre for Discovery Brain Sciences

18.  Investigating the Assembly Mechanism of the Peripheral Nervous System Node of Ranvier Elise Malavasi, Aniket Ghosh, Michele Zagnoni, Diane Sherman, Peter Brophy Center for Discovery Brain Science

19.  Myelin targeting in the CNS Anna Klingseisen, Ana-Maria Ristoiu, Peter Brophy and David Lyons Centre for Discovery Brain Sciences, Chancellor's Building, Little France, University of Edinburgh

20.  Importin-13 is a novel regulator of axon caliber and myelination Jenea M Bin1, Megan Madden1, Daumante Suminaite1, Silvia Benito1, Linde Kegel1, Eirinn Mackay2, Matthew Livesey1, David A Lyons1 1 Centre for Discovery Brain Sciences University of Edinburgh, 2Department of Cell and Developmental Biology, University College London, London

21.  Astrocytic glutamate transporter expression and function is induced by neuron-dependent Notch signalling as well as cyclic AMP Alison C Todd (1), Philip Hasel (1), David J A Wyllie (1) & Giles E Hardingham (1,2), 1. Centre for Discovery Brain Sciences, 2. UK Dementia Research Institute at Edinburgh

12.  *Activity-dependent presynaptic defects in mouse and rat CDKL5 deficiency Davenport E. C., Baxter P., Wyllie D. J. A.*, Hardingham G. E.*, Kind P. C.*, Cousin M. A.* Simons Initiative for the Developing Brain, The Patrick Wild Centre, UK Dementia Research Insitute and Centre for Discovery Brain Sciences, University of Edinburgh

22.  Epilepsy-associated mutation in SV2A disrupts synaptotagmin-1 function Callista Harper1, Darryl Low1, Catherine M Abbott2, Michael A Cousin1, 1Centre for Discovery Brain Sciences, Hugh Robson Building, George Square, University of Edinburgh, 2Medical Genetics Section, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh

23.  Synaptic Vesicle Recycling in Rodent Models of Fragile X Syndrome Katherine Bonnycastle, Jamie Marland, Peter Kind, Mike Cousin Centre for Discovery Brain Sciences, University of Edinburgh

24.  Changes in ribosome expression in fragile X syndrome and autism spectrum disorders Sang S. Seo, Susana R. Louros, Kate M. Homyer, Serena M. Linley-Adams, Kieron Scrimger, Hannah Wat, Emily K. Osterweil Centre for Discovery Brain Science, Patrick Wild Centre, Simons initiative for the Developing Brain, University of Edinburgh

25.  Zolpidem Sensitive Spontaneously Opening GABAA Receptors Regulate Hippocampal Granule Cell Excitability Nathanael O'Neill and Dr Sergiy Sylantyev Centre for Clinical Brain Sciences 

26.  Psychiatric disease aetiology and the t(1;11) translocation: an investigation via RNA-seq of IPSC derived neurons Shane T O’Sullivan, Helen S Torrance, Susan M Anderson, Phillippe Gautier, Daniel L McCartney, Karen Burr, Ellen Grünewald, Paraskevi Makedonopoulou, Mandy Johnstone, Barbara J Duff, Stephen Lawrie, Douglas HR Blackwood, Kathy L Evans, Colin Semple, Siddharthan Chandran, Andrew M McIntosh, David J Porteous, J Kirsty Millar Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh (STOS, HST, SMA, DLM, EG, PM, MJ, KLE, DJP, JKM), MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh (PG, CS), MRC Centre for Regenerative Medicine, University of Edinburgh, (KB, SC), Division of Psychiatry, University of Edinburgh (MJ, BJD, SL, DHRB)

27.  The role of DLG2 copy number variations in the pathophysiology of schizophrenia 1) Dr Panos Giannopoulos, 2) Susan Anderson, 3) Katerina Gospodinova, 4) Dr Mandy Johnstone, 5) Dr Kathy Evans, Centre for Genomic & Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital

28.  Identifying conserved regulators of motor neurone disease Rachel A Kline*$, Maica Llavero Hurtado*$, Laura C Graham*$, Samantha L Eaton*$, Thomas H Gillingwater$£, Paul A Skehel$£, Giuseppa Pennetta$£ and Thomas M Wishart*$.* The Roslin Institute and Royal (Dick) School of Veterinary Studies, $ The Euan MacDonald Centre for Motor Neurone Disease Research, £ The Centre for Integrative Physiology

29.  Molecular mechanisms of dopaminergic neurodegeneration in Caenorhabditis elegans Lourdes Riquelme-Domínguez1, Feng Xue1, Maria Doitsidou1. 1Centre for Integrative Physiology, University of Edinburgh

30.  Investigating the influence of TREM2 on microglial reactivity to inflammatory and age-related stressors Clare Latta and Barry McColl UK Dementia Research Institute, University of Edinburgh

31.  Endothelial cell dysfunction in cerebral small vessel disease is associated with white matter vulnerability Sophie F. Quick, Jonathan Moss, Rikesh M. Rajani,, Rosalind Brown, Amanda Boyd, Joanna M. Wardlaw, Anna Williams,  MRC Centre for Regenerative Medicine, The University of Edinburgh, UK Dementia Research Institute Centre, The University of Edinburgh, Centre for Clinical Brain Sciences, The University of Edinburgh

Neural Systems & Circuits

32.  Fronto-amygdala connectivity in a rat model of Fragile X syndrome Adam D Jackson (1,2,3,4), Sumantra Chattarji (2,4), David JA Wyllie (1,2,3,4), Peter C Kind (1,2,3,4) (1) Centre for Discovery Brain Science, The University of Edinburgh, (2) Simons Initiative for the Developing Brain, The University of Edinburgh, (3) Patrick Wild Centre, The University of Edinburgh, (4) Centre for Brain Development and Repair, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore India

33.  Neuronal activity and circuit alterations in a mouse model of SYNGAP1 haploinsufficiency Danai Katsanevaki

34.  Neuroligin-3 is required for the expression of typical fear responses, along with normal cellular excitability and plasticity in rats Natasha Anstey, Anna Toft, Shashank Tiwari, Vijayakumar Kapgal, Teresa Spano, Sumantra Chattarji, David Wyllie, Emma Wood, Oliver Hardt, Peter Kind Simons Initiative for the Developing Brain; Patrick Wild Centre; Centre for Brain Development and Repair, Instem, Bangalore, India; Centre for Discovery Brain Sciences, University of Edinburgh; McGill University, Montreal, QC, Canada

35.  GABAB Receptor Distribution and Function in Rat Neocortex Sam A Booker (1,2,3), David JA Wyllie (1,2,3), Peter C Kind (1,2,3), 1 - Centre for Discovery Brain Sciences, University of Edinburgh, 2 - Simons Initiative for the Developing Brain, University of Edinburgh, 3 - Patrick Wild Centre for Autism Research, University of Edinburgh

36.  Exploring the role of CNS myelination in larval zebrafish behaviour Megan Madden, Dr. Sigrid Koudelka, Dr. Jason Early, Dr. Eirinn Mackay, Dr. Isaac Bianco, Professor David Lyons Centre for Discovery Brain Sciences, Edinburgh, Neuroscience, Pharmacology & Physiology, UCL, Cell & Developmental Biology, UCL

37.  Structural changes in the axon initial segment contribute to altered neuronal excitability in rodent models of Fragile X Syndrome L Simoes de Oliveira, SA Booker, N Anstey, S Basu, AD Jackson, P Baxter, OR Dando, G Hardingham, D Sherman, PJ Brophy, DJA Wyllie, PC Kind Centre for Discovery Brain Sciences, University of Edinburgh, Simons Initiative for the Developing Brain, University of Edinburgh, Patrick Wild Centre, University of Edinburgh,  Centre for Brain Development and Repair, Instem, Bangalore, India

38.  The Black Box Effect: Reducing sensory stimulation after spatial learning promotes memory consolidation Daisy Arkell(1), Elizabeth Allison(1), Antonis Asiminas(1), Emma R Wood(1) and Oliver M Hardt(1,2) (1) Centre for Discovery Brain Sciences, University of Edinburgh, (2) Department of Psychology, McGill University, Montreal, Canada

39.  Electrophysiological characterisation of myelinated axon function in neural circuits Daumante Suminaite, Jenea Bin, Matthew Livesey and David Lyons Centre for Discovery Brain Sciences

Degeneration and Neuropathology

40.  Grey matter demyelination and synaptopathy in multiple sclerosis.  L.  Zoupi, S. Sekizar, T. Spires-Jone2 s & A. Williams1. 1. MRC Centre for Regenerative Medicine, SCRM Building, The University of Edinburgh, 2. Centre for Cognitive and Neural Systems, The University of Edinburgh

41.  An overview of the neurological phenotypes associated with the monogenic type I interferonopathies. Carolina Uggenti; Yanick J Crow.Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh

42.  Mendelian mutations in NRROS as a monogenic cause of microglial dysfunction in humans.  Carolina Uggenti; Yanick J Crow on behalf of clinical collaborators. Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh

43.  The clinical features of sporadic Creutzfeldt-Jakob Disease in the United Kingdom non-White population: a review of cases presenting to the UK National CJD Research & Surveillance Unit 1990-2017 Gavin Langlands, Graeme Mackenzie, Jan Mackenzie, Anna Molesworth, David Summers, Alison Green, Colin Smith, Richard Knight, Robert Will, Suvankar Pal National CJD Research & Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh

Cognition

44.  It's NICE to ECAS: The impact of training health professionals to identify cognitive and behavioural change in ALS Faith Hodgins*; Steve Bell**; Sharon Abrahams**The Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh; **Motor Neurone Disease Association

13.  *Can subtle changes in global atrophy and superior frontal gyrus be indicative of cognitive decline in late adulthood? A pilot study using The Alzheimer’s Disease Neuroimaging Initiative Database Stuart Reid (1), Maria Valdes-Hernandez (2), Shadia Mikhael (2), Cyril Pernet (2) (1) College of Medicine and Veterinary Medicine, University of Edinburgh, (2) Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh,

45.  Behavioural tagging and capture: memory persistence and memory-related neuronal ensembles in young and middle-aged rats Alexandra Gros, Amos Lim, Victoria Hohendorf, Nicole White and Szu-Han Wang Centre for Clinical Brain Sciences, The University of Edinburgh

46.  Sex differences in dissociable prefrontal correlates of cognitive and affective theory of mind Marcin A. Radecki1,2, Adam Moore1, Sarah E. MacPherson1,2,3, 1. Department of Psychology, University of Edinburgh, 2. Human Cognitive Neuroscience, University of Edinburgh, 3. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh

Clinical

47.  Are we really that good at lumbar punctures? An audit of lumbar puncture adverse events in the CDP CRF Dr Ines Lolosidi, Dr Claire Fugaccia (1), Dr Nicholas Charalambous and Professor Craig Ritchie Centre for Dementia Prevention, Edinburgh

48.  Symptoms of Psychiatric Disorders in People Living with ALS and their Family Members Caroline McHutchison, Andrew McIntosh, Marie Ryan, Emmet Costello, Mark Heverin, Laura Stephenson, Shuna Coville, Suvankar Pal, Siddharthan Chandran, Orla Hardiman & Sharon Abrahams,  Department of Psychology, University of Edinburgh, Academic Department of Neurology, Trinity College Dublin, Ireland, Anne Rowling Clinic of Regenerative Neurology, Edinburgh

49.  'A foreign concept': Alien limb in Sporadic Creutzfeldt-Jakob disease in the UK  Graeme Mackenzie, Jan Mackenzie, David Summers, Gavin Langlands, Anna Molesworth, Colin Smith, Alison Green, richard Knight, Robert Will, Suvankar Pal This report is independent research commissioned and funded by the Department of Health Policy research Programme and the Scottish Goverment 

50.  IL-1RA treatment does not exacerbate stroke-induced suppression of antimicrobial defence mechanisms Laura McCulloch (1), Stuart M. Allan (2), Craig J. Smith (2,3) Barry W. McColl (1) (1) UK Dementia Research Institute, Centre for Discovery Brain Sciences, University of Edinburgh, (2) Faculty of Biology, Medicine and Health, The University of Manchester, (3) Greater Manchester Neurosciences Centre, Salford Royal Hospitals NHS Foundation Trust

51.  Neuroimaging of Neuroeconomic Gameplay in Depression Siân E Robson (1), Viktoria-Eleni Gountouna (1), Heather C Whalley (2), Liana Romaniuk (2), Archie Campbell (1), David Porteous (1), Stephen M Lawrie (2), Kristin K Nicodemus (1) 1) University of Edinburgh Institute of Genetics and Molecular Medicine, 2) University of Edinburgh Centre for Clinical Brain Sciences

52.  The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in Alzheimer’s Disease and behavioural variant Frontotemportal Dementia. De Icaza Valenzuela, Monica M., Bak, Thomas H., Colville, Shuna, Pal, Suvankar, Abrahams, Sharon, 1. Human Cognitive Neuroscience – Department of Psychology, 2. Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), 3. Anne Rowling Regenerative Neurology Clinic, 4. Euan MacDonald Centre for Motor Neurone Disease research, 5. Centre for Clinical Brain Sciences, University of Edinburgh