Neuroscience Day 2019 - Poster Presentations

4.  Identification of a novel gene regulating myelinated axon caliber and synapse maintenance in the CNS, Jenea M Bin, Daumante Suminaite, Megan Madden, Silvia Benito, Linde Kegel, Matthew Livesey, David A Lyons, Centre for Discovery Brain Sciences, University of Edinburgh

5.  Disruption of the solute transporter NKCC1 in myelinating Schwann cells leads to severe peripheral nerve pathology, Linde Kegel1,, Katy LH Cole1,, Marion Baraban1, Rafael Almeida1, Matthew R Livesey2, Maria Rubio1, Anna Klingseisen1, Silvia Benito1, Jason J Early1, Richard J Poole3 and David A Lyons1, 1Centre for Discovery Brain Sciences, 2Centre for Clinical Brain Sciences, both University of Edinburgh, 3Department of Cell & Developmental Biology, University College London

6.  Do HCN channels link axonal activity and adaptive myelination?, Matthew Swire, Charles ffrench-Constant, Matthew Livesey MRC Centre for Regenerative Medicine, Centre for Discovery Brain Sciences, University of Edinburgh

7. New insights into the assembly and maintenance of the juxtaparanodal Kv1 complex, Nina Kozar, Dies Meijer, Centre for Discovery Brain Sciences & Edinburgh Centre for MS Research, University of Edinburgh

8.  Characterisation of intrinsic and synaptic properties of hippocampal neurons in Grin2a+/- and Grin2a-/- rats, Farhana Yasmin, Sam A. Booker, Neela K. Codadu, Sarfaraz Nawaz, Katie F. M. Marwick, Emma R. Wood, Peter C. Kind, Giles E. Hardingham and David J. A. Wyllie, Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, University of Edinburgh

9.  Computational > investigation of Neurogranin's influence on CaMKII activation using > KappaNEURON, Domas Linkevicius, David C. Sterratt Institute for Adaptive and Neural Computations, School of Informatics, University of Edinburgh

10.  An interactive website to investigate the developmental expression of genes associated with autism ,Owen Dando1,2,3, Zrinko Kozic1,2 and Peter Kind1,2,3, 1Simons Initiative for the Developing Brain, 2Centre for Discovery Brain Sciences, 3Patrick Wild Centre, all University of Edinburgh

11.  Laboratory Automated Interrogation of Data (LAB-AID): Ephys — An interactive website for the visualisation and analysis of electrophysiological properties in rodent models of autism, Zrinko Kozic1,2, Owen Dando1,2,3, Peter Kind1,2,3, 1Simons Initiative for the Developing Brain, 2Centre for Discovery Brain Sciences, 3Patrick Wild Centre, all University of Edinburgh

Neural Systems and Circuits

12.  Organisation of the medial entorhinal cortex output pathways, Sau Yee Tsoi, Zuzanna Bogdanowicz, Matthew Nolan, Gülşen Sürmeli, Centre for Discovery Brain Sciences, University of Edinburgh

13.  Comparative anatomy of the neuromuscular junction: Implications for larger animal models of neurodegenerative diseases, Ines Boehm, Ross A. Jones, Thomas H. Gillingwater, Edinburgh Medical School: Biomedical Sciences; Centre for Discovery Brain Sciences; Euan MacDonald Centre for Motor Neurone Disease Research, all University of Edinburgh

14.  Two stages of synaptic potentiation in the hippocampus during acquisition and consolidation of a contextual fear memory, Francesco Gobbo1,2, Bruno Pinto2,3, Ajesh Jacob2, Laura Cancedda3, Antonino Cattaneo2, 1Centre for Discovery Brain Sciences, University of Edinburgh 2Bio@SNS, Scuola Normale Superiore, Pisa, Italy, 3Department of Neuroscience & Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy

15.  Methylglyoxal, a glycolytic metabolite associated with painful diabetic neuropathy, alters C-fibre activity-dependent slowing in a sex-dependent manner, Atanaska Velichkova, Amy L. Hall, Carole Torsney, Centre for Discovery Brain Sciences, University of Edinburgh

16.  Zebrafish as an in vivo electrophysiology model for investigating myelinated axon function in neuronal circuit, Daumantė Šuminaitė, Jenea Bin, Matthew Livesey and David Lyons, Centre for Discovery Brain Sciences

17.  The Heading Encoding Circuit in the Insect Brain, John Pisokas School of Informatics, University of Edinburgh

18.  Imbalance if flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism, NJ Anstey1,2,3,4, V Kapgal2,3,4, AKH Toft1,2,3,4, S Tiwari2,3,4, T Spano2,3,4, S Nawaz1,2,3,4, S Chattarji2,3,4, DJA Wyllie1,2,3,4, ER Wood1,2,3,4, O Hardt2,3,4,5, PC Kind1,2,3,4, 1Centre for Discovery Brain Sciences, University of Edinburgh 2Centre for Brain Development and Repair, Instem, Bangalore, 3Simon’s Initiative for the Developing Brain, 4Patrick Wild Centre, both University of Edinburgh 5McGill University, Canada

19.  Experience-dependent changes in CA1 place cell spatial information and CA1 network activity are disrupted in Fmr1 KO rats, Antonis Asiminas1,2,3,4, Peter C Kind1,2,3,4, Emma R Wood1,2,3,4, 1Centre for Discovery Brain Sciences, 2Simons Initiative for Developing Brain, 3Patrick Wild Centre for Research into Autism, Fragile X Syndrome & Intellectual Disabilities, all University of Edinburgh 4Centre for Brain Development & Repair, Bangalore, India

20.  Impaired Functional Connectivity in a Rat model and Humans with Fragile X Syndrome, Joanna A.B. Smith1,2,3 , Andrew G. McKechanie1,2,4 , Milou Straathof5 , Rick M. Dijkhuizen5 , Sumantra Chattarji1,2,6 , Andrew C. Stanfield1,2,4 , Sally M. Till1,2,3 , Peter C. Kind1,2,3,6, 1Patrick Wild Centre, 2Simons Initiative for the Developing Brain, 3Centre for Discovery Brain Sciences, 4Centre for Clinical Brain Sciences, all University of Edinburgh 5Center for Image Sciences, University Medical Center Utrecht, The Netherlands, 6Centre for Brain Development and Repair, Instem, Bangalore, India

21.  Multifaceted homeostatic regulation of cellular excitability in Fmr1-/y mice, Laura Simoes de Oliveira, Sam A. Booker, Natasha J. Anstey, Paul S. Baxter, Owen R. Dando, Diane Sherman, Giles E. Hardingham, Peter J. Brophy, David J.A. Wyllie, Peter C. Kind, Centre for Discovery Brain Sciences; Simons Initiative for the Developing Brain; Patrick Wild Centre, both University of Edinburgh

Cognition

22. Phenome-wide association study of epigenetic age in the Lothian Birth Cohort 1936, Anna J Stevenson, Daniel L McCartney, Tara L Spires-Jones, Andrew M McIntosh, Ian J Deary, Riccardo E Marioni, 1Centre for Genomic & Experimental Medicine, 2Centre for Cognitive Ageing & Cognitive Epidemiology, 3Department for Psychology, 4UK Dementia Research Institute at Edinburgh, 5Centre for Discovery Brain Sciences, 6Division of Psychiatry, Centre for Clinical Brain Sciences, all University of Edinburgh

23. Genetic factors associated with recontact and mental health survey participation in a large population cohort, Mark J. Adams, David M. Howard, W. David Hill, Ian J. Deary, Andrew M. McIntosh, Division of Psychiatry, Centre for Clinical Brain Sciences, and Department of Psychology, both University of Edinburgh

24. Longitudinal trajectories of DNA methylation outliers and their associations with cognitive decline, Anne Seeboth1, Daniel L. McCartney1, Kathryn L. Evans1, Andrew M. McIntosh123, Sara Hägg4, Ian J. Deary125, Riccardo E. Marioni12, 1Centre for Genomic & Experimental Medicine, 2Centre for Cognitive Ageing & Cognitive Epidemiology, 3Division of Psychiatry, Centre for Clinical Brain Sciences, both University of Edinburgh 4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 5Department of Psychology

25. Validity of the English Version of the COMEGAM, Kym Craig, Daniel Hale, Pierre Mongeau, Catherine Grainger, Mary E. Stewart, Heriot-Watt University, University of Stirling; University of Quebec in Montreal

26. Development, Delivery and Assessment of the First Motorsport-Specific Concussion Education Programme, Dr Stephanie A. Adams, Anthony P. Turner, Hugh Richards, Peter J Hutchinson, Institute for Sport, PE & Health Sciences, Moray House School of Education, University of Edinburgh; Academic Division of Neurosurgery, Addenbrooke’s Hospital, University of Cambridge.

27. Concurrent validation of the UK Biobank cognitive assessment, Chloe Fawns-Ritchie and Ian J Deary. The Centre for Cognitive Ageing & Cognitive Epidemiology, Department of Psychology, University of Edinburgh

28. Generation Scotland - Using Electronic Health Records for Research, Archie Campbell, David Porteous, Rachel Edwards, Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh

29. Does the test order and the subject of study affect the performance of students on attentional tasks? Lihua Xia, Thomas Bak, Antonella Sorace, Mariana Vega-Mendoza, Psychology, University of Edinburgh

30. Lesions of the head direction cell system impair directional discriminations, Anna E. Smith1,2, Olivia A. Cheek1, Emily L.C. Sweet1, Paul A. Dudchenko 1,2, Emma R. Wood1, 1Centre for Discovery Brain Sciences, University of Edinburgh 2Psychology, School of Natural Sciences, University of Stirling

Development and Regeneration

31.  Investigating the Effects of 16p11.2 Deletion on Cerebral Development and Interneuron Production, Rana Fetit, Sarah Morson, Yifei Yang, Mandy Johnstone, Stephen Lawrie, Thomas Theil, Thomas Pratt, David Price, Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, both University of Edinburgh

32.  Understanding the role of 16p11.2 CNV genes in human cerebral corticogenesis, S. Morson, Y. Yang, D. J. Price, T. Pratt, Centre for Discovery Brain Sciences, University of Edinburgh

33.  Characterising INPP5E‘s role in forebrain development using human brain organoids, Bhuvaneish Selvaraj, James Cooper, Ariane Willems, Karen Burr, Mandy Johnstone, Siddharthan Chandran, Thomas Theil, Centre for Discovery Brain Sciences, University of Edinburgh

34.  Dissecting the contribution of innate immune cells to regeneration following demyelination, Sarah Neely, David Lyons, Centre for Discovery Brain Sciences, University of Edinburgh

35.  Imaging activity-dependent myelination in the developing zebrafish spinal cord, Helena Cornu, Rafael Almeida, David Lyons Centre for Discovery Brain Sciences, University of Edinburgh

36.  Neuronal activity accelerates myelin sheath growth within a critical period in vivo, Jill M Williamson, David A Lyons Centre for Discovery Brain Sciences, University of Edinburgh

37.  Independent regulation of targeting and growth orchestrates myelination by oligodendrocytes in vivo, Anna Klingseisen, Ana-Maria Ristoiu, Peter J. Brophy and David A. Lyons, Centre for Discovery Brain Sciences, University of Edinburgh

38.  Using zebrafish to study how neuronal activity regulates multiple aspects of myelination, Rafael Almeida, Sarah Lewis, David Lyons Centre for Discovery Brain Sciences, University of Edinburgh

39.  Chemical Screening with VAST, Jason Early, Katy Cole, David Lyons Centre For Discovery Brain Sciences, University of Edinburgh

40.  An automated Chemical Screen for Modulators of Brain Repair in Zebrafish, David Greenald, Bella Spencer, Nimra Rasheed, Leah Herrgen, Centre for Discovery Brain Sciences, University of Edinburgh

41.  How are brain structure and function restored after a mechanical injury? Francois Waharte, Leah Herrgen, Centre for Discovery Brain Sciences, University of Edinburgh

42.  Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo, Chiara Herzog1, Laura Pons Garcia1, Marcus Keatinge1, David Greenald1, Christian Moritz2, Francesca Peri2,3 and Leah Herrgen1, 1Centre for Discovery Brain Sciences, University of Edinburgh 2EMBL Heidelberg, Germany, 3Institute of Molecular Life Sciences, University of Zürich

43.  Development of a high-throughput screening platform for oligodendrocyte myelination (for progressive multiple sclerosis), (Jee Soo) Monica Kim1, Marie Bechler1, Anthony Buchoux2, Maaria Ginai3, Adam Stokes2, Anthony Callanan3, Mark Bradley4, Neil Carragher5, Charles ffrench-Constant1, 1MRC Centre for Regenerative Medicine, University of Edinburgh; 2Scottish Microelectronics Centre; 3School of Engineering; 4School of Chemistry; 5 Cancer Research UK Edinburgh Centre

44.  Central nervous system regeneration is driven by microglia necroptosis and repopulation, Amy F. Lloyd1, Claire L. Davies1, Rebecca K. Holloway1, Yasmine Labrak2, Graeme Ireland1, Dario Carradori2, Alessandra Dillenburg1, Eva Borger3, Daniel Soong1, Jill C. Richardson4, Tanja Kuhlmann5, Anna Williams3, Jeffrey W. Pollard1, Anne des Rieux2, Josef Priller6,7, Veronique E. Miron1, 1MRC Centre for Reproductive Health, University of Edinburgh; 2Louvain Drug Research Institute, Université Catholique de Louvain, Belgium; 3MRC Centre for Regenerative Medicine; 4Neurosciences Therapeutic Area Unit, GlaxoSmithKline R&D Ltd, Stevenage; 5Institute of Neuropathology, University Hospital Muenster, Germany; 6Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité Universitätsmedizin Berlin, Germany; 7UK Dementia Research Institute at Edinburgh

45.  Enhancing remyelination with CRISPR/Cas9 edited human oligodendrocyte precursor cells, L.J. Wagstaff, A. Fidanza R.J.M. Franklin, A.C. Williams, MRC Centre for Regenerative Medicine; MS Society Edinburgh MS Centre, University of Edinburgh; Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge

Degeneration and Neuropathology

46.  Investigating the role of astrocytes in central nervous system remyelination, Irene Molina-González1,5, Z. Jiwaji2,3,4, O. Dando2,3, G. Hardingham2,3,5, S. Chandran2,4,5, V. E. Miron1,5, 1MRC Centre for Reproductive Health, 2Edinburgh Dementia Research Institute, 3Centre for Discovery Brain Sciences, 4Centre for Clinical Brain Sciences, 5Edinburgh Centre for Multiple Sclerosis Research, all University of Edinburgh

47.  Brain hypoxia in remyelination, Ana-Maria Rondelli1, Kamil R Kranc2, Sarah R Walmsley3, Anna Williams1, 1MRC Centre for Regenerative Medicine, University of Edinburgh 2Queen Mary University of London, Centre for Haemato-Oncology Barts Cancer Institute, 3MRC Centre for Inflammation Research

48.  NRF2 in Stroke due to Intracerebral Haemorrhage: a Histopathological Study, Edward Christopher1, 2, Jeremy Hughes3, Rustam Al-Shahi Salman2, Colin Smith2, 1College of Medicine & Veterinary Medicine, 2Centre for Clinical Brain Sciences, 3MRC Centre for Inflammation Research, all University of Edinburgh

49.  Investigating the role of TREM2 in an experimental model of chronic cerebral hypoperfusion, Stefan Szymkowiak1, Karen Horsburgh2, Barry McColl1, 1UK Dementia Research Institute at Edinburgh, 2Centre for Discovery Brain Sciences, University of Edinburgh

50.  ATP11BKO Rat: a potential new model for Small Vessel Disease, Sophie Quick, Rikesh Rajani, Anna Williams, MRC Centre for Regenerative Medicine, University of Edinburgh

51.  Effects of APOE genotype on microglial phagocytosis of synapses in human post-mortem tissue in Alzheimer’s disease, Makis Tzioras, Karla Popovic, Colin Smith, Christopher Henstridge, Barry McColl, Tara Spires-Jones, Centre for Discovery Brain Sciences; UK Dementia Research Institute at Edinburgh; Centre for Clinical Brain Sciences, all University of Edinburgh

52.  A "Living" Systematic Review of Alzheimer's Disease Studies, Kaitlyn Hair, Emily Sena, Malcolm Macleod CAMARADES, Centre for Clinical Brain Sciences, University of Edinburgh

53.  Meta-Analysis of Preclinical Neurological Data in Drug Discovery Research Ezgi Tanriver-Ayder1, Christel Faes2, Tom Van De Casteele3, Sarah McCann4, Malcolm Macleod1, 1Centre for Clinical Brain Sciences, University of Edinburgh, 2Hasselt University, 3Janssen Pharmaceutica NV, 4Charité Universitätsmedizin Berlin

Clinical

54.  Characterising the genetic and epigenetic architecture of neurological protein biomarkers in the Lothian Birth Cohort 1936, Robert F. Hillary1, Daniel L. McCartney1, Sarah E. Harris2,3, Anna J. Stevenson1, Anne Seeboth1, Qian Zhang4, David C. Liewald2, Kathryn L. Evans1, Craig W. Ritchie5, Elliot M. Tucker-Drob6,7, Naomi R. Wray4, Allan McRae4, Peter M. Visscher4, Ian J. Deary2,3 and Riccardo E. Marioni1,2, 1Centre for Genomic & Experimental Medicine, 2Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh 3Department of Psychology, 4Institute for Molecular Bioscience, University of Queensland, Australia, 5Centre for Dementia Prevention, Centre for Clinical Brain Sciences, 6Department of Psychology, University of Texas at Austin, USA, 7Population Research Center, University of Texas at Austin, USA

55.  An investigation of factors influencing prescribing practice of Riluzole in Scotland, Kiran Jayaprakash, Judith Newton, Bernard Pang, Emily Beswick, Richard Davenport, George Gorrie, Ian Morrison, Shuna Colville, Siddharthan Chandran, Suvankar Pal, on behalf of the CARE-MND Consortium Centre for Clinical Brain Sciences; Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh; Anne Rowling Regenerative Neurology Clinic, Royal Infirmary of Edinburgh; Department of Clinical Neurosciences, NHS Lothian; Department of Neurology, NHS Tayside; Institute of Neurosciences, NHS Greater Glasgow & Clyde, Glasgow

56.  What is the Role of mHealth in Traumatic Brain Injury? A Systematic Review of the App Markets and the Literature, Edward Christopher1, Kareem Alsaffarini2, Aimun Jamjoom3 1College of Medicine & Veterinary Medicine, University of Edinburgh; 2College of Life Sciences and Medicine, University of Aberdeen; 3Centre for Clinical Brain Sciences