PhD Position in Epigenetic Regulation of Neuroimmunity in Alzheimer’s Disease

Based at University Medical Center Groningen (Netherlands), this PhD project aims to uncover how genetic risk influences immune cell function in AD by integrating single-nucleus epigenomic profiling of brain immune cells with high-resolution spatial transcriptomics.
  • € 3,108 to € 3,939 gross per month
  • Full-time
  • Fixed term: initial appointment of 12 months with extension up to a total of four years upon satisfactory progress.
  • University Medical Center Groningen, NL

This PhD project aims to uncover how genetic risk influences immune cell function in AD by integrating single-nucleus epigenomic profiling of brain immune cells with high-resolution spatial transcriptomics. The PhD candidate will characterize epigenetic and transcriptional states of immune cells in post-mortem human brain tissue and map these states in relation to disease pathology in AD tissue. In parallel, immune responses will be modeled in human stem cell–derived systems to identify regulatory mechanisms driving immune dysfunction.

Deadline for applications
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