Organelle dynamics in health and disease: bridging molecules to organisms

Membrane-bound organelles, together with the cytoskeleton and the molecular motors, are responsible for the transport of intracellular components required for almost all cellular functions and communication across the lifespan of a eukaryotic cell. Emerging research shows that organelle contact sites and cytoskeletal interactions are key regulatory hubs critical for processes like metabolism, signalling, and protein trafficking. On the other side, disruptions in organelle dynamics are increasingly linked to neurodegeneration, cancer, and metabolic disorders. Cutting-edge imaging, molecular biology, and biophysical tools allow for the real-time tracking and manipulation of organelles. This improves our understanding of organelles in physiological and pathological contexts, offering new targets for therapeutic interventions in human diseases. By bringing complementary insights from the molecular machinery of organelles trafficking to its implications in synaptic function, immune signalling, and metabolic regulation, this EMBO Workshop will foster a unique interdisciplinary dialogue.