Prof. Seth Grant Personal Chair of Molecular Neuroscience Current research interests Our current research is focussed on uncovering the scope, dynamics and functional impacts of synapse diversity throughout the brain, helping us to understand: the molecular mechanisms of innate and learned behaviourhow information is stored and recalled in synapse diversityhow the synaptome architecture of the brain changes throughout the lifespanthe impacts of disease on the brain synaptome – synapse vulnerabilities and resilience These studies are underpinned by on-going advances in the computational analysis of imaging data and the development of routes to integrate synaptomics among complementary brain ‘omics initiatives to maximize health discovery value. Research in a nutshell We aim to understand how the structure and organisation of synapses in the brain, in particular the diversity of the postsynaptic proteome, informs the fundamental mechanisms of learning, memory and behaviour, how these processes change naturally during the lifespan, and how they go awry in neurological dysfunctions such as schizophrenia and Alzheimer’s disease. Full research profile, including publications https://www.research.ed.ac.uk/en/persons/4b4c6fb7-906b-4cd9-84ba-14fc5ac06a32
