Prof. Seth Grant
- Personal Chair of Molecular Neuroscience
Organisation Associations
Current research interests
Our current research is focussed on uncovering the scope, dynamics and functional impacts of synapse diversity throughout the brain, helping us to understand:
- the molecular mechanisms of innate and learned behaviour
- how information is stored and recalled in synapse diversity
- how the synaptome architecture of the brain changes throughout the lifespan
- the impacts of disease on the brain synaptome – synapse vulnerabilities and resilience
These studies are underpinned by on-going advances in the computational analysis of imaging data and the development of routes to integrate synaptomics among complementary brain ‘omics initiatives to maximize health discovery value.
Research in a nutshell
We aim to understand how the structure and organisation of synapses in the brain, in particular the diversity of the postsynaptic proteome, informs the fundamental mechanisms of learning, memory and behaviour, how these processes change naturally during the lifespan, and how they go awry in neurological dysfunctions such as schizophrenia and Alzheimer’s disease.