Major Project Award from Alzheimer's Research UK

Tau protein aggregation is a hallmark of Alzheimer's disease and several related dementias, but there are currently no effective treatments that directly target tau. The project will use a translational pipeline spanning Drosophila, mouse and human brain tissue to identify proteins that modify tau toxicity and could represent promising new therapeutic targets. By combining large-scale genetic screening with validation in mammalian and human models, the research aims to identify new avenues for therapeutic development in Alzheimer's disease and related dementias.  

If you would like to read more about their work, there is also a new preprint out this week from Edmond Mouofo and James on 'Sexually dimorphic behavioural signatures of tau toxicity in adult Drosophila' (link below). This work highlights the importance of incorporating sex as a biological variable and provides a platform for mechanistic and translational studies of tauopathy.