My primary research and clinical focus is bipolar disorder. I have conducted work on the classification, genetic epidemiology and treatment of bipolar disorder. I have also been active in data science approaches and in work to understand the complex interface between major mental illness and cardiometabolic disease. My current primary focus is sleep, circadian science and mental illness.

I lead the interdisciplinary MRC-funded UK Circadian Mental Health Network and I am PI for two major Wellcome Trust programme grants on bipolar disorder, called AMBIENT-BD and HELIOS-BD.

I am a co-lead for a new Wellcome Discretionary Award called ENERGISE-BD: "Evaluating Nutritional Ketosis versus NHS EatWell Guidelines for Bipolar Depression: Single Blind Phase III Randomised Controlled Trial."

I also lead the new interdisciplinary Hub for Metabolic Psychiatry (2024-2029), which is part of the UKRI Mental Health Platform. I am Co-Director of the Chronobiology Task Force of the International Society for Bipolar Disorder.