My current CJD research uses human tissue-based approaches and cellular and cell-free model systems to:

Determine whether definable molecular strains underlie the clinico-pathological heterogeneity of human prion diseases.

Define the cellular risk factors for susceptibility to human prion infection

Develop sensitive and discriminatory tests for human prions

Determine the risks to human health associated with emergent animal prion diseases

Investigate the effects of molecular chaperones on the process of pathological protein misfolding