Dr.Miron’s lab focuses on harnessing the regenerative properties of inflammation to support central nervous system myelin health across the lifespan. Myelin is critical for neuronal health and function and its dysregulation contributes to common neurological conditions such as cerebral palsy, multiple sclerosis, and cognitive decline in ageing. More specifically, Dr.Miron's lab focuses on how central nervous system resident macrophages (microglia) support myelin heath, by answering the following questions:

1) DEVELOPMENT: How do central nervous system resident macrophages (microglia) support myelin formation in development? How is this disrupted following injury to the developing brain?

2) ADULTHOOD: How do microglia support the regeneration of myelin following injury? What other immune cells impact or complement their function in this context?

3) AGEING: How do microglia support myelin health in homeostasis and with ageing? How does this contribute to function e.g. cognitive decline?

Dr.Miron's lab uses a breadth of approaches to answer these questions, such as RNA sequencing (bulk, single-cell, translatome), digital spatial profiling, bioinformatics, human tissue analysis, mouse transgenics, in vivo mouse models, ex vivo mouse brain explants, in vitro human and mouse cell cultures, high throughput cell profiling and drug screening, microscopy (confocal, slide scanning, electron), molecular analyses and manipulation, and bioengineering drug delivery approaches.